Among the proteins involved in integrin signaling (Supplemental Figures 2A–C), our data show reduced levels of both beta (β)-actin (ACTB), required for embryonic development and cell recruitment (65), and Ras-related C3 botulinum toxin substrate 2 (RAC2), whose activation has been linked to infantile-onset combined immunodeficiency and susceptibility to viral infections (66). The gene discussed is RAC2; the disease is viral infectious disease.