Current composite inflammatory indicators used to predict or diagnose the development of SIRS after PCNL include neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), systemic systemic immune inflammation index (SII), prognostic nutritional index (PNI), albumin-globulin ratio (AGR), and hypersensitive C-reactive protein-albumin ratio (hs-CRP/Alb). The gene discussed is CRP; the disease is systemic inflammatory response syndrome.