While the initial analysis did not detect robust CD8+ T cell responses from the Moderna vaccine by intracellular cytokine staining (36), a subsequent study using MHC-I specific CD8 T cell sorting showed one or two doses of mRNA vaccines induced polyfunctional CD8 T cells with magnitudes comparable to natural viral infection, and with faster kinetics as compared to induction of CD4+ and neutralizing antibody responses (37). The gene discussed is CD8A; the disease is viral infectious disease.