In this space, cytokines and chemokines such as TGFβ1, IL-6, IL-6Rα and IL-8 (CXCL8) drive the tumor toward an aggressive mesenchymal state, while IL-10, IL-1RA and TGFβ1 actively suppress expression of immune effector functions (4). The gene discussed is TGFB1; the disease is neoplasm.