Although granzyme B is known chiefly as an effector molecule which, in conjunction with perforin, mediates T-cell and NK-cell cytotoxic effector responses, soluble granzyme B is also associated with the immunosuppressive tumor niche (43) and is secreted directly by breast (44) and urothelial tumor cells, where it’s presence is associated with tumor EMT and invasion (45, 46). The gene discussed is PRF1; the disease is neoplasm.