HES1 and tuberculosis: On the other hand, the molecules of the Notch pathway (Notch1, DLL1 and Hes1) were superior to the factors of Th1 cells (T-bet and IFN-γ) and the WBC parameters in terms of diagnostic efficacy for discriminating mild from moderate/severe TB, with AUC values of 0.897, 0.853 and 0.753, for Notch1, DLL1, and Hes1, respectively (Figure 5C).