In addition, both in HCC patients and murine models, LRPPRC exhibited a positive interaction with PD-L1, with negative correlations to CD8+, and CD4+ T-cell infiltrations and chemokines CXCL9, and CXCL10, indicating the possible role of LRPPRC in modulating anti-tumor immunity and immune infiltration. The gene discussed is CD274; the disease is hepatocellular carcinoma.