However, it could potentially also be interesting to investigate the role of Cdkn2a/Arf in the context of clonal MC diseases like mastocytosis or MC leukemia.So far, a CDKN2A mutation was only described in a case report of a patient suffering from MC leukemia with persistent myelodysplastic syndrome (72) without further characterization. This evidence concerns the gene CDKN2A and myelodysplastic syndrome.