Zebrafish have been widely used as a model organism for cancer research due to their high fecundity, low cost, accessibility for the modeling of various cancers, and transparent embryos for in vivo imaging.34–36 They were applied for studying biology related to the STING pathway.37,38 Therefore, in this study, we chose zebrafish for developing a tumor model to investigate our photoactivatable STING agonist in vivo. This evidence concerns the gene STING1 and cancer.