In particular, the ER membrane protein STING has been regarded as crucial in regulating such effects and has received increasing attention from scientists not only to shed light on its physiological functions but also to develop modulators targeting the STING adaptor for various diseases.10–12 Indeed, given the potential benefits of STING activation in tumor immunotherapy, numerous companies and institutes have dedicated themselves to discovering STING agonists to treat cancer. The gene discussed is STING1; the disease is cancer.