VEGFA and retinopathy of prematurity: Lynch et al. (36) and Badeeb et al. (37) showed that PROM was a protective factor for severe ROP, possibly because pregnant mothers who develop PROM are more likely to receive glucocorticoids, which plays an important role in promoting the maturation of the cerebrovascular system by downregulating VEGF to improve angiogenesis and systemic circulation (38).