It includes three age-dependent clinical phenotypes: neonatal intrahepatic cholestasis caused by citrin deficiency(NICCD), adult-onset type II citrullinemia (CTLN2) and failure to thrive and dyslipidemia caused by citrin deficiency (FTTDCD) between NICCD and CTLN2 stages (1). Here, SLC25A13 is linked to metabolic syndrome.