Mechanistically, HRD-EXCUTE prompts higher tumor mutation burden and more neoantigens to inflame tumor microenvironment, significantly boosting B cells, CD4+ T cells, CD8+ T cells, etc. Moreover, we found that the HDAC deacetylation was significantly activated in HRD patients without HRD-EXCUTE. This evidence concerns the gene HDAC9 and hypoparathyroidism-retardation-dysmorphism syndrome.