MAP3K5 and lymphoma: Inhibition of Prdx1 has been reported to stimulate apoptosis in hepatocellular 38, lymphoma 39, and lung cell lines 40 by increasing ROS levels and/or modulating kinase signaling pathways, such as MAPKs, Abelson tyrosine-protein kinase 1 (c-ABL), Myc proto-oncogene protein (c-MYC), apoptosis signal-regulating kinase 1 (ASK1), or STATs.