BCAP31 and Insulin resistance: Reduced lipolysis leaded to enhanced lipid accumulation and TAG content in adipocytes, resulted in the formation of supersized LDs, which is in agreement with the observation of increased TAG content in OA-induced sh-BAP31 preadipocytes (Figure 5H), also keeping consistency with the previous study of that BAP31-deficiency in hepatocytes promoted hepatic lipid accumulation and worsened insulin resistance 21.