PYGL and cancer: Furthermore, we showed that, in PDAC hypoxic microenvironment, elevated PYGL could strongly mobilize glycogen accumulation to fuel glycolysis, which could be inhibited by CP-320626, in consistent with previous studies that glycogen phosphorylases act as the rate-limiting enzymes of glycogenolysis to exert their functions in several cell types, such as cancer and dendritic cells 8, 19, 21.