We have long focused on the function of the transcription factor KLF5 in regulating BLBC stemness24, 25 which is of high expression in BLBC and indicated poor prognosis in high grade breast cancer patients (Figure S2A-C), and found that EphA2 may be positively regulated by KLF5 based on the transcriptome analysis of shKLF5/shCon HCC1806 and HCC1937 cells (Figure 2A). Here, EPHA2 is linked to breast cancer.