We discovered downregulation of mito-fusion protein OPA1 (mitochondrial dynamin-like 120-kDa protein) and MFN2 (mitofusin-2) and upregulation of mito-fission protein DRP1 (dynamin-related protein 1) in tumor cells with SIRT1 KO (Figure 6E). The gene discussed is SIRT1; the disease is neoplasm.