NLRP3 and diabetic kidney disease: Similarly, in diabetic nephropathy, the total flavones of Abelmoschus manihot (TFA) inhibit the pyroptosis of podocytes under high glucose conditions by regulating METTL3-dependent m6A modification and inhibiting the activation of the NLRP3 inflammasome and PTEN/PI3K/Akt signaling 128.