ALKBH5 and familial pancreatic carcinoma: In pancreatic cancer, ALKBH5 plays a pro-oncogenic role and ALKBH5 overexpression can promote tumor progression by downregulating potassium two-pore domain channel subfamily K member 15 and WISP2 antisense RNA 1 (KCNK15-AS1), an oncogene, to promote tumor growth invasion and metastasis 74.