In addition, METTL3 improves the resistance of HCC cells to sorafenib by stabilizing FOXO3 mediated by YTHDF1 in an m6A-dependent manner, thereby inhibiting the expression of autophagy-related genes including ATG3, ATG5, ATG7, ATG12, and ATG16L1 102. Here, METTL3 is linked to hepatocellular carcinoma.