IGFBP2 and central nervous system cancer: We then decided to identify the miR-6760-5p downstream target(s) using the StarBase, miRDB, miRWalk and miRGator datasets 32, 36-38, and IGFBP2, SRSF1, and EMP3 were identified (Figure 4A). To validate the specific target, miR-6760-5p mimics and inhibitors were introduced into glioma cells, respectively, and the transcripts of IGFBP2, SRSF1, and EMP3 were examined by RT-PCR.