IGF2BP2 and central nervous system cancer: Among the candidate interacting partners, DHX9 and IGF2BP2 caught our attention for the following reasons: 1) the specificity of GSCAR binding; 2) the molecular weights for the most significant differentially detected proteins in SDS‒PAGE; and 3) consistent with a previous study, we showed that IGF2BP2 and DHX9 interact with each other 43, which were increased in gliomas and positively correlated with GSCAR expression and adverse clinical outcomes (Figure 6C-6D and Figure S6B-6D).