One recent study found that lncRNA HIF1A-AS2 interacted with IGF2BP2 and DHX9 to stabilize HMGA1 mRNA 46, and HMGA1 has been shown to promote glioma malignant progression by activting the PI3K/Akt/c-Jun signaling pathway 61. The gene discussed is HIF1A; the disease is central nervous system cancer.