In line with previous findings in vitro, GSCAR knockdown markedly inhibited tumor growth in vivo, as evidenced by the decreased Ki67 and increased cleaved caspase 3 (CC3) immunohistochemical (IHC) staining signals, which could be overcome by SRSF1 overexpression (Figure 4L-4O). Here, SRSF1 is linked to neoplasm.