Comparison of tumorigenesis in these 88 mice with that in the control mice, which carry only mammary-specific Brca1 knockout by MMTV-Cre or WAP-Cre (Brca1-MSK n=118), indicating that the mice with Fgf pathway activation exhibited much faster tumor progression than the control mice (Fig. 6D). Here, SIK1 is linked to neoplasm.