Recent reports indicated that SARS-CoV-2 efficiently avoids the anti-viral functions of autophagy, regulating autophagy by interaction of its factors ORF3 and NSP6 with cell host autophagic factors such as WIPI2 or LAMP2 proteins 57, two proteins altered in response to the serums from COVID-19 patients. Here, WIPI2 is linked to COVID-19.