The extracellular ATP sends a “finding-me” signal to DC progenitors and macrophages, thereby promoting the recruitment of myeloid cells to the tumor; HMGB1 binds multiple pattern recognition receptors expressed by myeloid cells to activate immunity; the exposed CRT serves as an “eating-me” signal and promotes the phagocytosis of tumor cells by phagocytes 27. This evidence concerns the gene HMGB1 and neoplasm.