RAC1 and opiate dependence: Meanwhile, NSC23766, one of Rac1 inhibitors, could disrupt SK current and increase neuronal firing, while downregulation of Rac1 reduced the expression of SK channels in IL and inhibited morphine-induced CPP (Qu et al., 2020), indicating that Rac1 signaling pathway reduced neuronal excitability by regulating SK channel in PFC after morphine withdrawal, and this could help shed light on the mechanisms of opioid dependence and the development of treatment strategies.