Interestingly, The interaction between estrogen and ERβ in chondrocytes could induce proteoglycan and collagen biosynthesis, which would maintain the homeostasis of the cartilage tissue (Richmond et al., 2000; Ham et al., 2004), as well as 17β-estradiol could suppress NPC apoptosis (Wang et al., 2021). Here, ESR2 is linked to nasopharyngeal carcinoma.