SREBF1 and metabolic syndrome: In addition, propolis intake also affected lipid metabolism-related proteins in mice, such as peroxisome proliferator-activated receptor alpha (PPAR α), sterol-regulatory element binding protein 1 (SREBP-1), and 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA), therefore, propolis may improve body fat accumulation and dyslipidemia by affecting the expression of fat accumulation and lipid metabolism-related proteins (57), which was the same result as another report (59).