Since adipose tissue is a major reservoir for both vitamin D and VDR expression (25), we studied VDR mRNA expression in paired samples of visceral (VAT) and subcutaneous (SAT) adipose tissue (AT) from 120 subjects with a wide range of body fat mass, fat distribution and obesity related diseases and investigated whether fat distribution impacts 25(OH)D levels. Here, VDR is linked to obesity due to melanocortin 4 receptor deficiency.