The circadian rhythm of mice and the expression of circadian genes can be disrupted by the occurrence of ischemic stroke (Beker et al., 2018), including Rev-erbα, Per1, Clock and Bmal1. In our study, we found that cerebral ischemia induced decreased expression of circadian genes, including Rev-erbα. The gene discussed is BMAL1; the disease is Cerebral ischemia.