Acute SKA-31 treatment also enhanced endothelium-dependent vasodilation in arteries from older, non-T2D subjects (i.e., mean age of 71 years) (Mishra et al., 2021), and since aging is known to promote endothelial dysfunction (Donato et al., 2018; Ungvari et al., 2018), aged human resistance arteries responded to KCa channel facilitation similarly to what we previously reported in aged rat arteries (John et al., 2020). This evidence concerns the gene CSN3 and endothelial dysfunction.