CLPP and triple-negative breast carcinoma: We have shown the more potent activators of ClpP (TR compounds) result in depletion of mtDNA in vivo, as well as a ClpP-dependent loss of oxygen consumption rate (OCR) and protein-level expression of many mitochondrial metabolic, transcriptional, and homeostatic proteins in triple-negative breast cancer (TNBC) cells (Fennell et al., 2022).