In addition, early multiple inactivated influenza vaccination exerts a positive immunomodulatory effect in the APP/PS1 Alzheimer’s disease mouse model by preventing Treg-mediated systemic immune tolerance, maintaining microglial activation, and removing β-Amyloid plaques, which eventually improves cognitive deficits (Yang et al., 2020). This evidence concerns the gene APP and early-onset autosomal dominant Alzheimer disease.