In 2-month-old mice, 8 days post infection with H7N7 a significant decrease in GFAP fluorescent intensity was evident in the CA1 (Δ30%, p = 0.01, Figure 8A) and dentate gyrus (Δ36%, p = 0.01, Figures 8B, C) hippocampal subregions of unvaccinated mice compared with control mice inoculated with PBS, indicating reduced GFAP expression induced by H7N7 during the acute phase of the disease [CA1: two-way ANOVA Finfection(1, 8) = 7.17, p = 0.02; DG: two-way ANOVA Finfection(1, 8) = 9.99, p = 0.01]. This evidence concerns the gene GFAP and infection.