NOTCH1 and colonic neoplasm: Withaferin-A also possesses its apoptotic action on human colon cancer cells through inhibition of the Notch-1 signalling pathway and down-regulating pro-survival pathways, such as Akt/NF-κB/Bcl-2 in three colon cancer cell lines (HCT-116, SW-480, and SW-620) (Koduru et al., 2010; Kumar et al., 2015; Tewari et al., 2022).