Withaferin-A has been shown to inhibit the heat shock protein 90 (Hsp90) and induce heat shock protein 70 & 27 (Hsp27 & Hsp27), whereas the former causes aggregation of τ protein, which is the hallmark of Alzheimer’s disease, the latter has a protective role because these inhibit the oligomerization of amyloid-beta in mouse and drosophila larval model of Alzheimer’s disease (Sinadinos et al., 2013; Blair et al., 2014; Das et al., 2021). The gene discussed is TBXT; the disease is early-onset autosomal dominant Alzheimer disease.