In xenografted animal models of tumor and HeLa cells, CBS downregulated the expressions of nuclear-translocated p65 and molecules downstream of NF-κB (XIAP, Bcl-xL, MMP-2, MMP-9, COX-2, and cyclin D1) by inhibiting the NF-κB signaling pathway (Ma et al., 2017). The gene discussed is MMP2; the disease is neoplasm.