TP53 and neoplasm: In recent years, owing to the in-depth study of cancer pathogenesis, tumorigenesis is found to be related to the transduction of many signaling pathways, including JAK-STAT3, NF-κB, MAPK, p53, PI3Ks-Akt-mTOR, Wnt and others, and these are considered important in regulating key functions of human tumor cells (Zhu et al., 2022; Song et al., 2022; Kobayashi et al., 2020).