ACLY and neoplasm: Multiple enzymes within the FA synthesis pathway which include ATP-citrate lyase (ACLY) (Bauer et al., 2005; Hatzivassiliou et al., 2005), acetyl-CoA carboxylases (ACC1/2) (Jones et al., 2017; Ye et al., 2019), FA synthase (FASN) (Flavin et al., 2010; Fhu and Ali, 2020), and stearoyl-CoA desaturase (SCD1) (Roongta et al., 2011; Mason et al., 2012; Chen et al., 2016; Luis et al., 2021) have all been found to correlate strongly with tumor growth and have been proposed as biomarkers for specific types of cancers.