Several studies (Chen et al., 2014; Jiang et al., 2016; Bär et al., 2022) have indicated that SFN inhibits HDAC to prevent cell proliferation and induce apoptosis, leading to the downregulation of E2F3 and Ki-67, and activation of p21, bax and caspase-3 in cancer cells. This evidence concerns the gene HDAC9 and cancer.