This protein exploits the SA signaling pathway and the activation of the PR1 and PR5 genes, which lie behind the plant defense against biotrophic pathogens, such as On. Moreover, the activation of the POD gene in the C4-expressing plants might be associated with alleviation of oxidative damage caused by scavenging ROS, which are produced in response to the fungal infection. Here, TMEM37 is linked to fungal infectious disease.