Among those tested for SARS-CoV-2, PLWH who tested positive had lower rates of chronic renal disease (11% versus 12%, p = 0.030), higher rates of obesity (40% versus 33, p = 0.046), and higher median nadir CD4 + T lymphocyte counts (533 versus 413, p = 0.036). The gene discussed is CD4; the disease is obesity due to melanocortin 4 receptor deficiency.