Reduced‐HMGB1 can inhibit pluripotent vascular stem cell proliferation and differentiation, whereas oxidized‐HMGB1 loses its ability to inhibit the proliferation and differentiation of these cells, indicating that HMGB1 with different redox states may regulate atherosclerosis (Meng et al., 2018). The gene discussed is HMGB1; the disease is atherosclerosis.