CAT and hepatocellular carcinoma: In the study conducted in the Moroccan population (96 cases and 222controls) by Ezzikouri et al. [28], GPX1 SNP alone did not influence the risk of HCC development; however, MnSOD Ala/Ala in combination with GPx1 Leu/Leu, and MnSOD Ala/Ala in combination with CAT TT had both a pronounced risk of HCC development.