NFE2L2 and Familial prostate cancer: Recently, investigations have reported a number of SNPs (rs6721961, rs6726395, rs10506328, rs3124761, rs17458086, rs1630747, rs35652124, and so on) in NRF2 gene to the risk of various cancer including renal cell carcinoma [12, 13], pancreatic cancer [14], breast cancer [15, 16], prostate cancer [17], bladder cancer [18].