In our present study, differing from the above reports, we found that a significant association between NRF2 rs6721961 polymorphism and risk of HCC development was not observed in the entire population but only in older subjects, with respective adjusted OR of 2.148 (95% CI: 1.208–3.818, P = 0.009). The gene discussed is NFE2L2; the disease is hepatocellular carcinoma.