TGFB1 and polycystic ovary syndrome: When investigating the association between fibrillin 3 expression and PCOS, one study concluded that “since fibrillins are stromal matrices and since the ovarian stromal compartments are altered in women with PCOS, fibrillin 3 expression in the developing fetal ovary, via the activity of TGFβ to regulate stromal formation and function, could predispose an individual to PCOS in later life” [48].