The researchers found that the women with PCOS had a mean IL-1α blood concentration of 401.40 pg/ml, whereas the control group had a mean of 19.32 pg/ml only [11], concluding that hyperandrogenism is positively correlated with increased production of IL-1α, which in turn inhibits estradiol secretion [11]. The gene discussed is IL1A; the disease is hyperandrogenism.