As mentioned earlier, hyperandrogenism in PCOS promotes increased production of the IL-6-producing Th1 cells, neutrophils, and M1 macrophages; because of the resultant increase in IL-6 concentration, there is increased activation of the AKT pathway, which contributes to two features of PCOS [24, 25, 27]. The gene discussed is IL6; the disease is polycystic ovary syndrome.