Additionally, the activation of NF-κB is correlated with the formation of the NLRP3 protein that then binds to pro-Caspase-1 and ASC to form the NLRP3 inflammasome; this inflammasome then promotes the production of IL-1β and IL-18, ultimately contributing to the inflammatory state in PCOS [40]. Here, NFKB1 is linked to polycystic ovary syndrome.