PCK1 expression was significantly associated with smaller tumor diameter (tumor diameter ≤ vs. > 5 cm; 14.13% vs. 6.76%, P = 0.009), less bowel wall invasion (T stage) (T1 + T2 vs. T3 + T4; 23.07% vs. 8.00%, P = 0.002), and history of alcohol intake (never vs. ever; 12.40% vs. 4.81%, P = 0.031) (Table 3). This evidence concerns the gene PCK1 and neoplasm.