PCK1 and colorectal carcinoma: In addition, we reveal, for the first time, that PCK1 can inhibit CRC cell proliferation and colony formation by targeting the ubiquitination-autophagy axis (PCK1/UBAP2L Ser 454 phosphorylation/autophagy); this result highlights a molecular mechanism with potential for application in development of new strategies targeting gluconeogenesis-ubiquitination- autophagy pathways.