With this background, the present study aimed to unveil the possible correlation between SLC11A1 variants, including rs3731865G/C, rs3731864 (577-18G/A) in intron 5, and rs17235416 + TGTG/−TGTG polymorphisms and the risk of T2DM in an Iranian population. This evidence concerns the gene SLC11A1 and type 2 diabetes mellitus.