With the PSA values, however, while we do not have histological ambiguity, other factors may influence the PSA amount measured such as the age of the patient, the size of the prostate, different kinds of secondary conditions such as inflammations or infections, etc. These factors, nevertheless, do not necessarily affect the PSMA binding properties and activity retention and the variation they introduce in the final PSA value may thus affect the accuracy of our PSA correlation analysis with the generated TACs as well. Here, KLK3 is linked to infection.