SIRT2 and early-onset autosomal dominant Alzheimer disease: These SNPs can affect the binding ability of microRNAs to SIRT2 mRNA, thereby downregulating SIRT2 protein expression and contributing to disease development.16,17 Previous studies have linked rs2015 and rs2241703 in the 3′ UTR of SIRT2 to Alzheimer’s disease and Parkinson’s disease 16-18.