TP53 and neoplasm: The remarkable importance of the TP53 gene in safe-guarding an organism against tumor progression and neoplastic transformation has been proven by Mantovani et al.17 The TP53 tumor suppressor is important for genome constancy and cellular homeostasis via orchestrating a variety of procedures and effector pathways, comprising cell cycle control, apoptosis induction, and G1 arrest in the event of genotoxic stress during duplication.