VEGFA and neoplasm: Additionally, stromal cells, comprising cancer-associated fibroblasts, adipocytes, and tumor-associated macrophages (TAMs), have been revealed to be related to tumor progression through a diversity of procedures (namely, generating a vessel network that helps in the nutrition of the cancer bulk as well as the secretion of vascular endothelial growth factor A (VEGF-A) via TAMs causing cancer infiltration).22