Wang et al39 have pointed out that The deletion of an F-box only protein 8 (FBX8), a major component of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases, has been linked to colon tumorigenesis acceleration, according to Wang et al.37 Through the ubiquitination process, FBXB caused GSTP1 to be degraded, which slowed the growth of colorectal cancer. The gene discussed is FBXO8; the disease is colorectal cancer.