In addition to protein levels, NSD3 induces global H3K36 dimethylation in pancreatic cancer cells and influences the mRNA levels for genes including ADAM28, ADAM9, BIRC3, CXCL5, DUOX2, GABRP, ITGB6, and RAB11FIP1. This evidence concerns the gene DUOX2 and familial pancreatic carcinoma.