CD274 and neoplasm: In the current investigation, it is worth noting that CNIH4 correlates positively with immunosuppressive cells (M2 macrophages) and negatively with anti‐tumor immune cells (CD8+ T cells, CD4+ T cells, B cells, NK cells, and M1 macrophages), as well as an abundance of immune checkpoint molecules like CD274, HAVCR2, CTLA4, LAG3, SIGLECT15, and PDCD1.