However, a previous study [46] has demonstrated that the absence of other pituitary deficiencies, along with IGF-I SDS levels > − 0.52 indicates a low pretest probability of GHD; in the current study, we aimed to further emphasize this concept by rising the threshold of IGF-I SDS to values ≥ 0. The gene discussed is IGF1; the disease is pituitary deficiency.