But the results showed a non-significant enrichment (empirical P > 0.05) for the P-value thresholds from P < 5.0 × 10–02 to P < 5.0 × 10–04.rs2275994, located at 18 kb downstream of GRHL2, was the most significant SNP within the deafness loci (HR = 3.85, 95% CI 2.24–6.61, P = 1.10 × 10–06; Fig. 2C and Table S9). This evidence concerns the gene GRHL2 and deafness.