NFKBIA and central nervous system cancer: By cisplatin and radiation cytotoxicity analysis, we found that higher expression of NFKBIA gene was significantly associated with lower cisplatin IC50 (that is, lower tolerance to cisplatin) in CNS cancer cell lines (ρ = − 0.416, P = 0.005; Fig. 1F), while the expression of NFKBIA gene was not associated with radiosensitivity in the cell lines (ρ = 0.118, P = 0.500), indicative of a harmful function of NFKBIA against cisplatin-induced injury.