Using cisplatin and radiation cytotoxicity analysis, we found that lower expression levels of GRHL2 were significantly correlated with lower radiation SF2 (that is, lower tolerance to radiation) in CNS cancer cell lines (ρ = 0.341, P = 0.045; Fig. 2G), while the expression of GRHL2 was not significantly associated with cisplatin sensitivity in the cell lines (ρ = 0.045, P = 0.768), indicative of a protective effect of GRHL2 on radiation-related damage. The gene discussed is GRHL2; the disease is central nervous system cancer.