In addition, PD occurs in some instances in the absence of LBs, for instance, PD without nigral degeneration-SWEDD (Ling et al. 2016; Milber et al. 2012), post-encephalitic PD (Jellinger 2009), acute MPTP-induced parkinsonism (Burns et al. 1984), PINK 1 autosomal early PD (Takanashi et al. 2016; Schneider and Alcalay 2017) and LRRK2 (PARK 8) late-onset PD (Pont-Sunyer et al. 2017). Here, LRRK2 is linked to Parkinson disease.