PPARGC1A and posterior cortical atrophy: A “PGC1α target” custom gene set was generated from the top 123 genes upregulated upon PGC1α expression in the human PC3 PCa cell line (Table S1) and used as readout of PGC1α activity.22 In agreement with the upregulation of Ppargc1a, there was significant enrichment of PGC1α target genes in Pten−/−;AmpkACT versus Pten−/− mice (Figure 2F).