PRKAB1 and posterior cortical atrophy: These genes encode proteins that function at different stages of the cell cycle, raising the possibility that chronic AMPK activation can regulate multiple stages of the cell cycle in parallel, not just the G1-to-S transition or G2-to-M transition, as reported previously.7,30–32 The expression of a subset of these genes (10 of 32) was decreased by pharmacological activation of AMPK in C4–2 cells, and we termed this subset of genes the “AMPK-cell cycle” gene network because their expression is significantly changed following AMPK activation in mouse and human PCa cells.