One way to address this issue would be to activate AMPK pharmacologically in a mouse model of late-stage PCa, and in this regard, it is interesting to note that a mouse model of PCa metastasis has been described recently.47 We do show that pharmacological activation of AMPK significantly slows tumor growth in a xenograft model, suggesting that AMPK can prevent disease progression. This evidence concerns the gene PRKAB1 and neoplasm.