Genomic aberrations of PTEN are among the most common in human PCa; PTEN is progressively lost through disease progression, and complete loss is predominant in advanced and metastatic disease.8The prostate-specific Pten-null PCa mouse is an important and clinically relevant model that accurately recapitulates the different stages of the human disease, albeit on a more rapid timescale.9 The gene discussed is PTEN; the disease is posterior cortical atrophy.