PTEN and cancer: It is interesting to speculate whether more widespread activation of AMPK could have further protective effects on cancer progression, mediated by changes in whole-body metabolism in response to feeding an HFD.11,41 Lipidomics analysis of mouse prostate tissue revealed a significant reduction in the abundance of a number of lipid classes, including the major neutral storage lipids (triglycerides and diglycerides), in Pten−/−;AmpkACT mice compared with Pten−/− mice.