PPARGC1A and posterior cortical atrophy: Importantly, PGC1α has been shown previously to suppress PCa progression and metastasis by promoting a catabolic metabolic program characterized by increased fatty acid oxidation, decreased lipogenesis, and increased intracellular ATP.22 Consistent with this previous study, we show that overexpression of PGC1α in human PCa cells increases ATP levels, lowers the rate of cell proliferation, and decreases cell invasiveness.