CASP3 and posterior cortical atrophy: These data suggest that AMPK activation dampens pro-inflammatory signaling, which has been shown to drive PCa development, progression, and metastasis.18,19 No change in apoptosis, as detected by staining for cleaved caspase-3, was seen between tissue sections isolated from Pten−/− or Pten−/−;AmpkACT mice (Figure S3C).