NT-proBNP (N-terminal pro-B-type natriuretic peptide) is a cardiac biomarker that has been linked to incident AF and stroke in previous research.5–11 Data from several randomized trials also showed that adding NT-proBNP to the CHA2DS2-VASc score significantly improved the prediction of stroke in patients with AF.9–11 However, data on the relationship between NT-proBNP and effects of AF screening are lacking. This evidence concerns the gene NPPB and Stroke.